Norio Akuta Selected Research

Lamivudine (Epivir)

5/2017	Efficacy of long-term tenofovir-based rescue therapy in patients with chronic hepatitis B refractory to nucleoside/nucleotide analogs.
6/2014	Long-term efficacy and emergence of multidrug resistance in patients with lamivudine-refractory chronic hepatitis B treated by combination therapy with adefovir plus lamivudine.
3/2014	Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B.
5/2010	Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients.
4/2010	Clinical and virological effects of long-term (over 5 years) lamivudine therapy.
2/2010	Development of HCC in patients receiving adefovir dipivoxil for lamivudine-resistant hepatitis B virus mutants.
2/2010	Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment.
3/2009	Efficacy of entecavir treatment for lamivudine-resistant hepatitis B over 3 years: histological improvement or entecavir resistance?
6/2008	Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
1/2008	Changes in viral loads of lamivudine-resistant mutants during entecavir therapy.

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Norio Akuta Research Topics

Disease

87	Hepatocellular Carcinoma (Hepatoma) 10/2022 - 01/2002
56	Infections 10/2019 - 01/2002
52	Chronic Hepatitis C 12/2020 - 01/2002
50	Chronic Hepatitis B 02/2022 - 01/2002
45	Fibrosis (Cirrhosis) 01/2022 - 01/2002
28	Liver Cirrhosis (Hepatic Cirrhosis) 02/2020 - 01/2002
26	Neoplasms (Cancer) 04/2022 - 01/2003
26	Hepatitis 01/2014 - 01/2002
19	Liver Diseases (Liver Disease) 01/2022 - 01/2002
17	Chronic Hepatitis (Chronic Active Hepatitis) 03/2014 - 01/2003
15	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2011
15	Hepatitis B 01/2022 - 01/2002
11	Carcinogenesis 01/2014 - 01/2003
10	Type 2 Diabetes Mellitus (MODY) 01/2022 - 03/2009
10	Hepatitis C 11/2015 - 09/2005
9	Anemia 10/2014 - 07/2004
8	Diabetes Mellitus 01/2022 - 11/2008
6	Liver Neoplasms (Liver Cancer) 04/2022 - 12/2010
5	Disease Progression 01/2021 - 01/2004
5	Viremia 01/2017 - 01/2007
4	Insulin Resistance 01/2022 - 06/2009
4	Virus Diseases (Viral Diseases) 04/2021 - 01/2004
4	Body Weight (Weight, Body) 01/2018 - 10/2007
4	Hypertension (High Blood Pressure) 03/2014 - 09/2009
4	Persistent Infection 10/2013 - 05/2005
3	Fatty Liver 04/2022 - 09/2009
3	Hepatic Encephalopathy 12/2019 - 10/2004
3	Lymphoma (Lymphomas) 12/2019 - 04/2003
3	Thrombocytopenia (Thrombopenia) 10/2017 - 05/2009
3	Liver Failure 09/2012 - 01/2004

Drug/Important Bio-Agent (IBA)

73	InterferonsIBA 12/2020 - 01/2002
38	Ribavirin (Virazole)FDA LinkGeneric 01/2018 - 01/2002
35	Lamivudine (Epivir)FDA Link 05/2017 - 01/2002
31	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2004
28	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2003
24	Hepatitis B e AntigensIBA 03/2014 - 01/2002
23	DNA (Deoxyribonucleic Acid)IBA 04/2022 - 02/2002
16	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2022 - 01/2002
15	Alanine Transaminase (SGPT)IBA 03/2016 - 01/2003
11	entecavir FDA Link 01/2022 - 06/2007
10	lenvatinibIBA 10/2022 - 01/2020
10	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2022 - 01/2003
10	AntigensIBA 01/2022 - 01/2002
10	Amino Acids FDA Link 09/2015 - 08/2008
7	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2022 - 08/2008
7	BilirubinIBA 10/2017 - 01/2003
7	miriplatinIBA 06/2017 - 01/2011
7	telaprevirIBA 10/2014 - 01/2010
6	AlbuminsIBA 01/2019 - 01/2009
6	Serum AlbuminIBA 10/2017 - 10/2007
6	adefovir dipivoxil (Hepsera)FDA Link 06/2014 - 01/2004
6	Transaminases (Aminotransferases)IBA 03/2012 - 08/2004
6	Interferon-betaIBA 01/2011 - 01/2008
5	Fetal Proteins (Fetoprotein)IBA 04/2021 - 09/2013
5	lipoarabinomannan (LAM)IBA 05/2017 - 06/2008
5	adefovirIBA 06/2014 - 01/2004
5	Proteins (Proteins, Gene)FDA Link 02/2011 - 03/2006
5	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/2011 - 01/2006
5	Interferon-alpha (Interferon Alfa)IBA 12/2010 - 02/2002
4	Pharmaceutical PreparationsIBA 10/2022 - 08/2012
4	NucleotidesIBA 02/2022 - 09/2004
4	Sodium-Glucose Transport ProteinsIBA 01/2022 - 01/2017
4	SofosbuvirIBA 01/2021 - 01/2017
4	Glucose (Dextrose)FDA LinkGeneric 02/2020 - 06/2012
4	asunaprevirIBA 09/2018 - 03/2016
4	daclatasvirIBA 09/2018 - 03/2016
4	Protease Inhibitors (Protease Inhibitor)IBA 01/2017 - 01/2010
4	Aspartic Acid (Aspartate)FDA Link 04/2010 - 05/2004
3	Biomarkers (Surrogate Marker)IBA 04/2022 - 01/2017
3	Cell-Free Nucleic AcidsIBA 04/2022 - 02/2020
3	CanagliflozinIBA 01/2022 - 05/2019
3	Biological ProductsIBA 01/2022 - 02/2009
3	Surface Antigens (Surface Antigen)IBA 01/2022 - 12/2002
3	TransferasesIBA 04/2021 - 08/2004
3	Tenofovir (Viread)FDA Link 04/2021 - 01/2014
3	NucleosidesIBA 05/2017 - 06/2007
3	CreatinineIBA 03/2014 - 03/2013
3	Dihydrotachysterol (AT 10)IBA 01/2014 - 03/2009
3	PlatinumIBA 03/2013 - 04/2009
3	Hemoglobins (Hemoglobin)IBA 10/2012 - 11/2004
3	Tyrosine (L-Tyrosine)FDA Link 04/2010 - 05/2004
3	Methionine (L-Methionine)FDA Link 04/2010 - 05/2004
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2006 - 02/2002
2	Tumor Biomarkers (Tumor Markers)IBA 04/2022 - 01/2008
2	tenofovir alafenamideIBA 02/2022 - 11/2021
2	Circular DNAIBA 01/2022 - 01/2019
2	Ferritins (Ferritin)IBA 01/2022 - 11/2018
2	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022 - 08/2020
2	acarboxyprothrombin (PIVKA)IBA 11/2021 - 02/2009
2	SodiumIBA 04/2021 - 11/2015
2	Ethanol (Ethyl Alcohol)IBA 01/2021 - 04/2016
2	HLA-DQB1 antigen (HLA DQB1)IBA 12/2020 - 01/2013

Therapy/Procedure

138	Therapeutics 04/2022 - 01/2002
15	Radiofrequency Ablation 02/2019 - 01/2002
6	Drug Therapy (Chemotherapy) 11/2021 - 11/2011
6	Drug Tapering 10/2013 - 07/2004
5	Aftercare (After-Treatment) 01/2022 - 12/2006
5	Retreatment 03/2019 - 04/2003
3	Hepatectomy 10/2020 - 11/2017
2	Punctures 04/2021 - 11/2014